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X-WR-CALNAME:GRK 2905 - Ultrafast Nanoscopy
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X-WR-CALDESC:Events for GRK 2905 - Ultrafast Nanoscopy
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DTSTART;TZID=Europe/Berlin:20241108T130000
DTEND;TZID=Europe/Berlin:20241108T140000
DTSTAMP:20260612T090311
CREATED:20241106T094650Z
LAST-MODIFIED:20241106T095249Z
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SUMMARY:Role Model Spotlight
DESCRIPTION:RUN auditorium \n\n\n\nDr. Ching-Ju Tsai \n\n\n\nLab. for Biomolecular Research\,PSI Center for Life Sciences\, Switzerland \n\n\n\nAre you pondering what to do after completing your PhD? Debating whether to stay in academia while considering starting a family? The challenge intensifies if your partner is also a scientist\, potentially in the same field. Balancing dual careers\, raising children\, and possibly relocating away from family and friends can be tough.Join us for an engaging “Role Model Spotlight” session\, featuring Dr. Ching-Ju Tsai\, as she shares her personal experiences and insights on navigating these challenges.We welcome the audience to actively participate by asking questions when we delve into questions like: \n\n\n\nUnderstanding the planable vs. unpredictable aspects of academic careers.Come join us for this insightful discussion\, complemented by coffee\, tea\, and some sweets. We look forward to your participation. \n\n\n\nStrategies and support systems for effectively managing dual career paths in academia. \n\n\n\nNavigating the unique challenges and opportunities of pursuing a scientific career while raising children. \n\n\n\nCritical transitions from earning a PhD to securing a permanent academic position. \n\n\n\n\n\n\n\n\n\nf \n\n\n\n\nSee announcement
URL:https://grk2905.de/event/role-model-spotlight/
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BEGIN:VEVENT
DTSTART;TZID=Europe/Berlin:20241108T140000
DTEND;TZID=Europe/Berlin:20241108T150000
DTSTAMP:20260612T090311
CREATED:20241001T132420Z
LAST-MODIFIED:20241108T134936Z
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SUMMARY:Special lecture:Investigating ultrafast nanoscale dynamics with electrons and X-rays
DESCRIPTION:RUN auditorium \n\n\n\nProf. Dr. Sascha Schäfer \n\n\n\nRegensburg center for ultrafast nanoscopy \n\n\n\nAs an introduction to the lecture by Jörg Standfuss\, I will give an overview on current methodologies in ultrafast electron and X-ray imaging with a focus on:(1) the key properties of available pulsed sources\,(2) a comparison between imaging\, diffraction and holograpy approaches and(3) important limitations by beam-induced sample damage. \n\n\n\n\n\n\n\n\n\nf \n\n\n\n\nSee announcement
URL:https://grk2905.de/event/grk-colloquium-tba/
CATEGORIES:Special lecture series
ATTACH;FMTTYPE=image/webp:https://grk2905.de/wp-content/uploads/2024/01/Schaefer.webp
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BEGIN:VEVENT
DTSTART;TZID=Europe/Berlin:20241108T150000
DTEND;TZID=Europe/Berlin:20241108T160000
DTSTAMP:20260612T090311
CREATED:20241106T094030Z
LAST-MODIFIED:20241108T134915Z
UID:1471-1731078000-1731081600@grk2905.de
SUMMARY:Colloquium: Photopharmacology Across Time and Space: Molecular Insights via X-ray Free Electron Lasers
DESCRIPTION:RUN auditorium \n\n\n\nDr. Jörg Standfuss  \n\n\n\nLab. for Biomolecular Research\, PSI Center for Life Sciences\, Switzerland \n\n\n\nStructural biology has been critical for our understanding of how proteins work on the molecular level. However\, resolving the temporal evolution of biological macromolecules in response to activating stimuli—such as the binding of small molecular ligands or drug molecules—remains a challenge. In recent years\, our research group has leveraged X-ray Free Electron Laser facilities to experimentally investigate how retinal-binding rhodopsins\, acting as pumps\, channels\, or light sensors\, are activated at the atomic level across a wide range of time scales. \n\n\n\n\n\n\n\n\n\nf \n\n\n\n\nSee announcement\n\n\n\n\n\n\nIn our latest experiments at the Swiss X-ray Free Electron Laser\, we explored how photoactive azobenzene compounds\, mimicking retinal\, can be used to trigger protein dynamics for structural studies. My presentation will focus on the dissociation dynamics of the photopharmacological drug candidate azo-combretastatin A4 from tubulin\, capturing events from the initial photochemical reaction in the femtosecond range\, through the disruption of high-affinity protein-ligand interactions in nanoseconds\, adaptation of the binding pocket in microseconds\, and the eventual release of the compound in milliseconds. I will discuss the relevance of these findings for our understanding of how anti-cancer drugs destabilize the microtubule network. Furthermore\, I will propose the use of azobenzene-based photoswitches to trigger G protein-coupled receptors and other pharmacologically relevant targets in time-resolved structural biology experiments.
URL:https://grk2905.de/event/colloquium-photopharmacology-across-time-and-space-molecular-insights-via-x-ray-free-electron-lasers/
CATEGORIES:Colloquium
ATTACH;FMTTYPE=image/jpeg:https://grk2905.de/wp-content/uploads/2024/09/Jorg-Standfuss-e1730886513313.jpg
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BEGIN:VEVENT
DTSTART;TZID=Europe/Berlin:20241115T140000
DTEND;TZID=Europe/Berlin:20241115T150000
DTSTAMP:20260612T090311
CREATED:20241001T133813Z
LAST-MODIFIED:20260326T162953Z
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SUMMARY:RTG Colloquium: Complexity with a purpose: Long range collective vibrations steering protein conformational change
DESCRIPTION:14:00 h \n\n\n\n\n\n\n\n\n\n\n\nRUN auditorium \n\n\n\nProf. Dr. Andrea Markelz \n\n\n\nUniversity at Buffalo College of Arts and Sciences \n\n\n\n\n\n\n\nThe evolutionary advantage of the large-scale structure of proteins surrounding the biochemically active site is not readily apparent. It has been speculated that the structural dynamics provide long-range control of access to the active site. Through anisotropic terahertz micro-spectroscopy (ATM) measurements we find that the photo initiation of orange carotenoid protein’s (OCP) photocycle is accompanied with switching in the protein structural vibrations\, before long range structural change can occur. The ATM spectral changes are reversible and calculations reproduce the changes in ATM spectra\, with features red shifted from the measurements. Averaging the vibrational displacement autocorrelation matrix over the spectrally relevant region and thermally occupied starting configurations finds changes in the correlations for residues 80-113 with residues 151-164\, and for residues 280-291 with residues 265-275. These regions are those previously predicted to be involved in the structural modification necessary for a critical step in the photocycle. The results provide the first evidence that structural vibrational change can actuate conformational change for function.
URL:https://grk2905.de/event/grk-colloquium-prof-dr-andrea-markelz/
CATEGORIES:Colloquium
ATTACH;FMTTYPE=image/jpeg:https://grk2905.de/wp-content/uploads/2024/10/Markelz-scaled-e1727789922881.jpg
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BEGIN:VEVENT
DTSTART;TZID=Europe/Berlin:20241129T140000
DTEND;TZID=Europe/Berlin:20241129T154500
DTSTAMP:20260612T090311
CREATED:20241001T143100Z
LAST-MODIFIED:20260326T162929Z
UID:1424-1732888800-1732895100@grk2905.de
SUMMARY:RTG lecture: Advancing biophysics using DNA Origami
DESCRIPTION:14:00 h \n\n\n\nProf. Dr. Dina Grohmann \n\n\n\nUniversity of Regensburg \n\n\n\n \n\n\n\nOver the last two decades – aiming to imitate efficient biological machineries – artificial nanostructures have been developed that form defined 2D- and 3D-shapes including carbon-nanotubes\, DNA origami and cyclodextrins. Among these\, DNA origami found a remarkable rise of interest spurred by its biocompatible properties combined with the possibility to precisely and accurately arrange functional molecules like proteins\, nanoparticles\, DNA “docking stations” for biomolecular assays and fluorescent probes. Recently\, a synthetic membrane channel and a DNA nanorobot solely build by DNA origami have been introduced demonstrating the variety of structures possible. In this talk\, I will introduce the highly innovative world of DNA origami and illustrate how it enabled new biophysical insights. I describe various applications of DNA origami: rulers and positioning devices\, force measurements and force application devices\, serving as support for biomolecules in cryogenic electron microscopy and super-resolution microscopy\, programmable nanopores.
URL:https://grk2905.de/event/grk-lecture-prof-dr-dina-grohmann/
CATEGORIES:Special lecture series
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